Higuchi connors phase solubility techniques

According to the classification method of Higuchi and Connors (Chen et al., Citation 2007; Higuchi & Connors, Citation 1965), ... Phase-solubility techniques. Adv Chem Instrum 4:117–212 [Google Scholar] Joo JI, Kim DH, Choi JW, Yun JW. (2010). Proteomic analysis for antiobesity potential of capsaicin on white adipose tissue in rats fed with a high fat diet.

16 Oca 2019 ... bAL: linear phase-solubility diagram and BS: phase-solubility diagram ... (30) Higuchi, T.; Connors, K. A. Phase-solubility techniques. In.The two kinds of CDs enhance the aqueous solubility of Res. As shown in Fig. 2, the phase-solubility diagrams of Res with β-CD or HP-CD show a linear relationship between the amount of Res solubilised and the concentration of CDs in solution (A L type diagram). According to the theory of Higuchi and Connors (1965), this may be attributed …phase solubility technique in studying the formation of complex salts of triamterene j pharm sci. 1964 nov;53:1325-8. doi: 10.1002/jps.2600531108.The most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that the drug...The most common and widely used method to evaluate the ability of the inclusion complex is the phase solubility studies by Higuchi and Connors (1965). 23 The plot showed that the drug...Phase solubility studies were conducted following the method reported by Higuchi and Connors . A standard curve of natamycin in methyl alcohol was prepared beforehand. Excess amounts of natamycin were added to 10 mL aqueous solution of ME-β-CD ranging in concentrations from 0 to 10 mM. To achieve equilibrium, the solutions …The phase purity of the cocrystal samples prepared by rapid solvent evaporation and simple evaporation techniques was examined by PXRD based on the presence or absence of the characteristic peaks of the corresponding individual components ... Higuchi T, Connors KA. Phase-solubility techniques. Advan Anal Chem Instr. …Phase-solubility studies were performed in triplicate by the method of Higuchi and Connors. ... Phase solubility techniques. Adv Anal Chem Instru 1965;4:17-123 ...

Jul 11, 2017 · Phase solubility study. The effect of complexation with βCD and HPβCD on the solubility of GA was assessed. The phase solubility diagram was used in order to evaluate the solubility of GA in the presence of CDs according to Higuchi & Connors . The amount of GA was kept in excess and mixed up with different concentrations of βCD (0–16 mM ... Oct 15, 2013 · Fig. 2 sums up the results of the phase-solubility studies performed and analyzed using the approach described by Brewster and Loftsson (2007) and Higuchi and Connors (1965). For this study, a range of CD concentrations were selected which cover the maximum solubility of CDs in water at room temperature: 0–160 mM for 2-O-MBCD and 0–320 mM ... 2.3. Solubility Measurements. Phase-solubility studies of benzoyl metronidazole in aqueous solutions of β-CD were carried out according to the Higuchi-Connors procedure . Various amounts of β-CD were generally dissolved in distilled water, and excess amounts of benzoyl metronidazole were loaded in glass vials. The vials were …Phase-solubility analysis. Phase-solubility study was carried out according to the method of Higuchi and Connors . Excess amount of repaglinide (approx. 10 mg) was added to 2.5 mL 10 mM phosphate buffer (pH 6 and pH 3.5) containing increasing amounts of Captisol ® (10 −3 –10 −1 M) and shaken at 25 ± 0.5 °C.Abstract. The interaction between ibuprofen and maltodextrins with different dextrose equivalent was studied in solution and solid state in order to investigate the effect on the solubility of ibuprofen and to determine their usefulness in terms of chiral recognition. Apparent binding constants were calculated using nuclear magnetic resonance ...The phase solubility curve was a typical AL-type curve, as described in solubility diagrams by Higuchi and Connors. A regression coefficient (R 2) exceeding 0.99 and slope value (0.0732) of less than 1 revealed the formation of the KME/HP-β-CD system with a 1:1 stoichiometry. The Ks of KME/HP-β-CD were calculated based on the …Abstract. This current work has been conducted mainly to increase solubility and drug release properties for high hydrophobic Dentatin (DEN) by incorporation it into …A stability indicating HPLC assay has been developed in order to investigate the effect of different factors on the stability of omeprazole. These factors included the pH with the tested values ranging from 6–10 and the temperature by monitoring the drug stability at 25, 37 and 40°C. The study was then extended to investigate the effect of ...

Phase-solubility techniques 来自 scienceopen.com 喜欢 0. 阅读量： 717. 作者： TK Higuchi ， A Connors.K. A. Connors and J. J. Lipari. Effect of cycloamyloses on apparent dissociation constants of carboxylic acids and phenols: Equilibrium analytical selectivity induced by complex formation. J.All the formulations were evaluated at pre and post compression level. Acid solubility profile showed higher solubility in HCl buffer pH2 (296.89±3.49 μg/mL). Mixture of propylene glycol and ...Phase solubility study. Phase solubility studies were carried out according to the method reported by Higuchi and Connors . Excess amounts of MMF were added to 0.1 N HCl solutions (pH-1.2) containing para sulphonatocalix[4]resorcinarene in different molar concentrations and these flasks were then sonicated for 1 h and shaken at a rate …

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ResearchGate | Find and share researchCitation University of Kansas. Kenneth Spencer Research Library Personal papers of Takeru Higuchi (PP 359) Articles arranged alphabetically by title: Higuchi A-Z; Higuchi et. al. A-Z Higuchi and Connors, "Phase-Solubility Techniques,", 1964 Dates Creation: 1964 Collapse All Get at Spencer Box: 11, Folder: 35 (Mixed Materials) Repository Detailswhere [D/CD] is the concentration of dissolved drug-cyclodextrin complex, [CD] is the concentration of dissolved free cyclodextrin and slope is the slope of the phase solubility profile (Higuchi, Connors, 1965 Higuchi T, Connors AK. Phase solubility techniques. In: Reilly CN, editor. Advances in Analytical Chemistry and Instrumentation.Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. View 20 related papers. About: The article was published on 1965-01-01 and is currently …Then K 1:1 is calculated from the slope and S 0 according to Higuchi and Connors : ... obtained from phase-solubility diagrams are most frequently observed constants that are composed of a number of true stability constants for multiple types of ... Higuchi, T., Connors, A.K.: Phase-solubility techniques. Adv. Anal. Chem. Instrum. 4, …

complexation is the phase so lubili ty method carr ied o ut according to Higuchi and Connors method [14][15] , which examines the e ffec t of nanospo nges on the solubility o f the drug. AnIndeed, the absorption coefficient of THC in the complex depends on ligand concentration within the solution. Solubility diagrams were obtained by plotting THC concentration versus MeβCD concentration. The association constant K is given by the Eq. (1) of Higuchi and Connors (Higuchi and Connors, 1965).Abstract. Solubility is one of the most important physicochemical properties studied during pharmaceutical preformulation. For liquid dosage form development, accurate solubility …The solubilizing potential and complexing tendencies of six cyclodextrins (CyD) with nifedipine in aqueous solution were evaluated using phase solubility methods. Solubility curves of nifedipine with β-CyD, 2-hydroxypropyl-β-CyD (2HP-β-CyD) and 2-hydroxypropyl-γ-cyclodextrin (2HP-γ-CyD) were classified as type AL, while for heptakis (2,6-dimethyl)-β-CyD (DIMEB), randomly methylated-β ...There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience. Phase-solubility studies were performed in triplicate by the method of Higuchi and Connors. ... Phase solubility techniques. Adv Anal Chem Instru 1965;4:17-123 ...Higuchi T, Connors K A 1965 Phase solubility techniques Advances in Analytical. Chemistry and Instrumentation vol 4(1) pp 117-212. 9. ITM Web of Conferences 45 ...Feb 28, 2023 · According to the classification of the phase solubility diagram of Higuchi and Connors (Eq. 1), the HO-AAVPA solubility profiles correspond to the type A L phase diagrams, which support the ...

Phase solubility analyses of F-Asta and Asta-E with HPβ-CD were performed following procedures similar to the ones reported previously (Higuchi & Connors, 1965; Schönbeck et al., 2017 ...

The phase solubility diagram for Nag in SBE-β-CD system is shown in Fig. 1. The apparent solubility of Nag increased linearly as a function of SBE-β-CD concentration over the studied concentration range, which could be classified as A L type according to Higuchi & Connors. The slope value was less than one, indicating that the formation of a ...Phase solubility studies. The phase solubility studies were performed using Higuchi and Connors method (Higuchi & Connors, 1965). Briefly, different concentrations of β-CD (0, 2, 6, 8, 10 and 20 mM) were prepared in deionised water in glass capped vials. To each vial 1 mg CUR was added.According to Higuchi and Connors’ theory, [17] the phase-solubility relationships between PD and β- and γ-CDs are classified as typical A L-type, ... according to the method reported by Higuchi and Connors (1965). ... Phase solubility techniques. Adv. Anal. Chem. Instrum., 4 (1965), pp. 117-212. View in Scopus Google ScholarFormulation Development and Solubility Enhancement of Voriconazole by Solid Dispersion Technique. Research J. Pharm. and Tech. 2020; 13(10):4557-4564. doi: 10.5958/0974-360X.2020.00803.3 Cite(Electronic): Gaurav Bhaduka, Jitendra Singh Rajawat. Formulation Development and Solubility Enhancement of Voriconazole by Solid Dispersion Technique.Higuchi T, Connors K A 1965 Phase solubility techniques Advances in Analytical. Chemistry and Instrumentation vol 4(1) pp 117-212. 9. ITM Web of Conferences 45 ...Phase solubility studies The phase solubility studies were carried out according to the method of Higuchi and Connors (Jansook et al. 2018 ; Higuchi & Connors 1965 ). Briefly, an excess of KME was added to 200 μL aqueous solutions of different HP-β-CD concentrations (1, 2, 4, 6, 8, and 10 mM).Phase solubility analysis was performed according to the method reported by Higuchi and Conners . An excess amount of RIF was added into a glass vial containing 1 mL of PBS solution (pH = 7.4) with various concentrations of ACB (0, 20, 40, 60, 80, 100 mM, respectively). ... Higuchi, T., Connors, K.A.: Phase-solubility techniques. Adv. …The K C and CE were calculated from the intrinsic solubility (S 0 ) in the complexing medium and the initial linear slope of the phase solubility diagram (Higuchi and Connors 1965;Loftsson et al ...

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method described by Higuchi & Connors et al [18]. Excess NSF (100 mg) was added to a 50 m L . ... [18] Higuchi T and Connors K A 1965 Phase solubility techniques Advances in Analyt ical Chemistry .All solubility measurements were performed six times. 2.2.2. Phase solubility study. Phase solubility study was performed according to the method described by Higuchi and Connors [17]. An excess amount of aceclofenac was placed in a 25 ml glass flask containing different concentrations of polymers in 20 ml distilled water.Solubility phase diagrams were created to evaluate the molar ratios of GAZ/βCD and GAZ/γCD inclusion complexes and their stability in aqueous solution (Fig. 2).The solubility of GAZ increased linearly with the added concentrations of βCD and γCD and produced an A L solubility phase diagram according to the classification by Higuchi, Connors et al. [12] A-type diagrams are formed when the ...Detection of inclusion complexation was done in solution by means of phase solubility analysis, mass spectrometry, and 1 H nuclear magnetic resonance (1 H-NMR) spectroscopic studies, and in solid state using differential scanning calorimetry (DSC), powder x-ray diffractometry (X-RD), scanning electron microscopy (SEM), and in vitro …Solubility studies used deionized water, and 1 H NMR spectra were of solutions in deuterium oxide (D 2 O, deuterium content 99.8%) from Fluka (Barcelona, Spain). 2.2. Phase solubility studiesSolubility measurements were carried out according to the method of Higuchi and Connors (1965). Excess amounts of clofibrate were added to a series of ...In this regard, the well-known solubility diagram design (T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212) should be done in order to obtain information about the drug solubility in presence of increasing CD concentrations.Abstract. Levemopamil was solubilized by varying the concentration of hydroxypropyl- β -cyclodextrin (HP β CD) and by the alteration of pH. The drug molecule has two sites for possible complexation with HP β CD, creating the possibility of either 1:1 or 1:2 complexation. The solubility as a function of HP β CD concentration of the charged ...Using the concept proposed by Higuchi and Connors , the solubility diagrams can be classified as the AL type. The observed increase of the drug solubility results from the formation of a drug-cyclodextrin inclusion complex with a stoichiometry of 1:1. ... Higuchi, T.; Connors, K.A. Phase solubility techniques. Adv. Anal. Chem. …Phase solubility studies. The phase solubility studies were performed using Higuchi and Connors method (Higuchi & Connors, 1965). Briefly, different …Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, pp. 117–212. Google ScholarHiguchi T, Connors K. Phase-solubility techniques. Adv Anal . Chem Instr 1965;4:117-22. ... Microwave Irradiation Technique, a Green Chemistry Approach for Dissolution Enhancement of Lopinavir.2.2. Phase solubility study. Analysis of phase solubility was implemented based on the method from Higuchi and Connors (Citation 1965). CAT (excess amount) was mixed with 20 mL of β-CD aqueous solutions in different concentration levels … ….

The phase solubility study of CDL with PSC[4]arene and PSC[6]arene were executed according to Higuchi and Connors . Phase solubility studies were accomplished at 27 °C temperature, in triplicate. Excess quantity of CDL (250 mg) was added into different conical flasks containing 150 mL aqueous solutions of PSC[4]arene and PSC[6]arene at …Phase solubility studies were performed by the method previously reported by Higuchi and Connors . Briefly, excess amounts of darifenacin were added to 20 mL of aqueous solutions containing various concentrations of Hp βCD ... T. Higuchi and K. Connors, “Phase solubility techniques,” Advances in Analytical Chemistry and …2.3. Solubility Measurements. Phase-solubility studies of benzoyl metronidazole in aqueous solutions of β-CD were carried out according to the Higuchi-Connors procedure . Various amounts of β-CD were generally dissolved in distilled water, and excess amounts of benzoyl metronidazole were loaded in glass vials. The vials were …Abstract Solubility is one of the most important physicochemical properties studied during pharmaceutical preformulation. For liquid dosage form development, accurate solubility data are essential to ensure the robustness of the finished product.Characterization of ternary complexes of meloxicam-HPβCD and PVP or L-arginine prepared by the spray-drying techniqueTernary complexes of meloxicam (ME) (a poorly water soluble anti-inflammatory drug) with hydroxypropyl-β-cyclodextrin (HPβCD) and either a hydrophilic polymer, namely, polyvinyl pyrrolidone (PVP) or a basic amino acid …2 May 2011 ... It has to be noted that in the Higuchi and Connors method applied, Kc was obtained from the apparent cholesterol solubility, which comprises ...The phase solubility curve can be classified as an A L-type diagram, according to the Higuchi and Connors classification (Higuchi and Connors, 1965). The slope of the solubility diagram (0.70) was lower than 1, indicating the formation of 1:1 (mol/mol) ACV-SBE-β-CD inclusion complex.Phase solubility evaluates the solubility of insoluble guest molecule in the presence of cyclodextrin. It can be obtained by studying the relationship between the guest molecule (1,8-cineole) and the host molecule (HP-β-CD) in the solution, and the stability of IC can be evaluated by stability constant (K s ) ( Higuchi & Connors, 1965 ). Higuchi connors phase solubility techniques, [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1], [text-1-1]